Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Utilization of Intravenously Infused Maltooligosaccharides in Rabbits
Shuji WATANABEShigeaki MARUOHideya MUKAIAkira MORINO
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1993 Volume 16 Issue 10 Pages 1044-1045

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Abstract

The utilization of intravenously infused maltotriose, maltotetraose and maltopentaose was investigated in rabbits. Rabbits were infused with isotonic solutions of each maltooligosaccharide for 2 h and the utilization was assessed by the 24-h urinary loss of carbohydrates. The utilization of these maltooligosaccharides was good (≥87.5%) at a rate of 1 ml/kg/h (≤250 mg/kg/h) and poor (≤36.2%) at a rate of 5 ml/kg/h (>250 mg/kg/h). Furthermore, these maltooligosaccharides infused as 5% solution showed good utilization (≥86.2%) at a rate of 5 ml/kg/h (250 mg/kg/h). These results suggest the existence of a threshold dose in the utilization of intravenously infused maltooligosaccharides, and this threshold value in rabbits is estimated to be nearly 250 mg/kg/h.

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