Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Characterization of Two Novel Polysaccharides Having Immunological Activities from the Root of Panax ginseng
Masashi TOMODAKeiko HIRABAYASHINoriko SHIMIZURyoko GONDANaoko OHARAKatsutoshi TAKADA
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1993 Volume 16 Issue 11 Pages 1087-1090

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Abstract

Two acidic polysaccharides, called ginsenan-S-IA and ginsenan S-IIA, were isolated from the root of Panax ginseng C. A. MEYER. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.6×104 and 1.0×105, respectively. Ginsenan S-IA is composed of L-arabinose : D-galactose : D-galacturonic acid in the molar ratio of 8 : 8 : 1, and ginsenan S-IIA is composed of L-arabinose : D-galactose : D-glucose : D-galacturonic acid in the molar ratio of 15 : 10 : 2 : 5, in addition to small amounts of O-acetyl groups. About a half (ginsenan S-IA) and about a quarter (ginsenan S-IIA) of the hexuronic acid residues exist as methyl esters. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and periodate oxidation studies indicated that their structural features include mainly α-1, 5-linked L-arabino-β-3, 6-branched D-galactan type structural units. Both polysaccharides showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test and pronounced anti-complementary activity. These substances are the first examples having a relatively high content of both α-3, 5-branched L-arabinose and β-1, 4-linked D-galactose units among the acidic arabinogalactans with activities on phagocytosis and anti-complement.

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