Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Carbonic Anhydrase Activators. VII. Isozyme II Activation by Bisazolyl-methanes, -ethanes and Related Azoles
Claudiu T. SUPURAN, Alexandru T. BALABAN, Pilar CABILDO, Rosa Maria CLARAMUNT, Jose Luis LAVANDERA, Jose ELGUERO
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Keywords: carbonic anhydrase, isozyme II, azole, bisazolyl-methane/ethane, pKa
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1993 Volume 16 Issue 12 Pages 1236-1239

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Abstract
A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.
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© The Pharmaceutical Society of Japan
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