Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Inhibition of DNA of Topoisomerase I Activity by Diethylstilbestrol and Its Analogues
Taiko ODA, Yoshihiro SATO, Masahiko KODAMA, Motohisa KANEKO
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Keywords: diethylstilbestrol, indenestrol, DNA topoisomerase, dienestrol, Chinese hamster V79 cell
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1993 Volume 16 Issue 7 Pages 708-710

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Abstract

Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (±)-indenestrol B, (±)-IB, showed the strongest inhibitory effect.

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