BIOSYNTHESIS IN VITRO OF 2-(3-AMINO-3-CARBOXYPROPYL)-ISOXAZOLIN-5-ONE, THE NEUROTOXIC AMINO ACID IN LATHYRUS ODORATUS

Fumio IKEGAMI; Ritsuko SAKAI; Tsutomu ISHIKAWA; Yu-Haey KUO; Fernand LAMBEIN; Isamu MURAKOSHI

doi:10.1248/bpb.16.732

Fumio IKEGAMI, Ritsuko SAKAI, Tsutomu ISHIKAWA, Yu-Haey KUO, Fernand LAMBEIN, Isamu MURAKOSHI

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Keywords: biosynthesis, 2-(3-amino-3-carboxypropyl)-isoxazolin-5-one, Lathyrus odoratus, Leguminosae, S-adenosyl-L-methionine, neurotoxic amino acid

JOURNAL FREE ACCESS

1993 Volume 16 Issue 7 Pages 732-734

DOI https://doi.org/10.1248/bpb.16.732

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Abstract

2-(3-Amino-3-carboxypropyl)-isoxazolin-5-one (ACl), a neurotoxic amino acid from Lathyrus odoratus, was confirmed to be derived enzymatically from S-adenosyl-L-methionine (SAM) and isoxazolin-5-one. Some properties of an enzyme in the biosynthesis of ACl are described.

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