Abstract
Effect of idebenone on the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective glutamate receptor was evaluated using Xenopus oocytes injected with RNAs encoding mouse α1 and α2 AMPA receptors. Concanavalin A augmented current responses of the RNA-injected oocytes to glutamate, kainate, and AMPA and these responses were further potentiated by 100 μM idebenone. The minimum concentration of idebenone that gave a significant potentiation was 10 μM for glutamate. These results suggest that idebenone acts on AMPA-selective glutamate receptor channels composed of α1 and α2 subunits.
