Anti-allergy Actions of Alkylphenyl α-D-Mannopyranosides

Abstract

The inhibitory effects of alkylphenyl α-D-mannopyranosides on histamine release from rat peritoneal mast cells induced by an antigen-antibody reaction were examined. Among the compounds tested, 2, 4, 6-trimethylphenyl α-D-mannopyranoside exhibited the strongest inhibitory effect. Furthermore, the 2, 4, 6-trimethylphenyl α-D-man-nopyranoside suppressed the Schultz-Dale reaction and 48 h homologous passive cutaneous anaphylaxis (PCA), suggesting that this compound may be a useful lead compound in the development of novel anti-allergy drugs.