ENHANCEMENT OF PHORBOL ESTER-INDUCED PRODUCTION OF TUMOR NECROSIS FACTOR-α BY 2, 6-DIMETHYLPHENYLPHTHALIMIDE

Abstract

The effect of phenyl- and benzylphthalimide analogs on tumor necrosis factor (TNF)-α production by a human leukemia cell line, HL-60, stimulated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was investigated. Though non-substituted phenyl- and benzyl-phthalimide had no effect on TNF-α production after TPA-induction, introduction of methyl group (s) onto the phenyl group resulted in the appearance of potent enhancing activity on TNF-α production.