1994 Volume 17 Issue 3 Pages 460-462
Karounidiol [D : C-Friedo-oleana-7, 9 (11)-diene-3α, 29-diol] and 7-oxodihydrokarounidiol [7-oxo-D : C-friedo-olean-8-ene-3α, 29-diol], isolated from the seeds of Trichosanthes kirilowii, were examined for the effect on 12-O-tetradecanoylphorbol-13-acetate (TPA, 1μg/ear)-induced inflammation, following application of this tumorpromoting agent, to the ears of mice. Both compounds inhibited the inflammatory activity induced by TPA and the 50% inhibitory dose for TPA-induced inflammation was 0.3 and 0.4 mg/ear, respectively. Furthermore, at 2 μmol/mouse, karounidiol markedly suppressed the promoting effect of TPA (1 μg/mouse) on skin tumor formation in mice following initiation with 7, 12-dimethylbenz [a] anthracene (50 μg/mouse).
