The Inhibitory Effect of Sulfated Schizophyllans and Related Oligosaccharides on Coagulation and Fibrinolysis

Akio HIRATA; Yoko NAGAMATSU; Wataru ITOH; Kengo TABATA; Junichiro YAMAMOTO; Yoshio OKADA

doi:10.1248/bpb.17.739

Akio HIRATA, Yoko NAGAMATSU, Wataru ITOH, Kengo TABATA, Junichiro YAMAMOTO, Yoshio OKADA

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Keywords: sulfated schizophyllan, sulfated oligosaccharide, inhibitory activity, plasmin, fibrinolysis, coagulation

JOURNAL FREE ACCESS

1994 Volume 17 Issue 5 Pages 739-741

DOI https://doi.org/10.1248/bpb.17.739

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Abstract

Sulfated schizophyllans and sulfated oligosaccharides were prepared and their inhibitory effects on coagulation and fibrinolysis were examined. Some sulfated schizophyllans, which had a sulfur content of more than 10%, prolonged prothrombin time (PT) and thrombin time (TT). Interestingly, some sulfated schizophyllans and related oligosaccharides were able to inhibit plasmin toward fibrinolysis and amidolysis.

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