Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Enzymatic Sulfation of Glycosides and Their Corresponding Aglycones by Arylsulfate Sulfotransferase from a Human Intestinal Bacterium
Lisa KONISHI-IMAMURAMakoto SATOKeiji DOHIShigetoshi KADOTATsuneo NAMBAKyoichi KOBASHI
Author information
JOURNAL FREE ACCESS

1994 Volume 17 Issue 8 Pages 1018-1022

Details
Abstract
A novel type of arylsulfate sulfotransferase (ASST) from a predominant human intestinal bacterium catalyzes the stoichiometric transfer of a sulfate group from phenolic sulfate esters to phenols. We clarified that polyphenols were better substrates of this enzyme than the corresponding glycosides. Additionally, a coumarin derivative, esculetin, was sulfated by ASST at the 6-position to give 6-monosulfate. Therefore, ASST is more useful for the preparation of sulfated polyphenols at their specific hydroxyl groups and would play an important role in the metabolism of phenolic compounds in vegetable food and traditional medicines.
Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top