Anti-inflammatory Effect of 22-Oxa-1α, 25-dihydroxyvitamin D₃ on Carrageenin-Induced Inflammation in Rats

Abstract

The anti-inflammatory effect of 22-oxa-1α, 25-dihydroxyvitamin D₃ [22-oxa-1α, 25 (OH)₂D₃], an analogue of the active form of vitamin D₃, was studied regarding carrageenin-induced inflammation in rats. In the early phase of the inflammation, the formation of granulation tissue and the weight of exudate were significantly suppressed by both oral and local administrations of 22-oxa-1α, 25 (OH)₂D₃ daily for 4d (day 0-3) after carrageenin injection, though the local injection of 22-oxa-1α, 25 (OH)₂D₃ (7 and 10μg/kg). Similarly, oral and local administrations of 22-oxa-1α, 25 (OH)₂D₃ from day 4 to 7 significantly suppressed the increase in exudate and the proliferation of granulation tissue in the late phase of carrageenin-induced inflammation in rats. The results suggest that 22-oxa-1α, 25 (OH)₂D₃ has an anti-inflammatory activity on both the acute and proliferative phases of inflammation in rats.