Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Effects of Steroidal Glycosides on Blood Glucose in Normal and Diabetic Mice
Atsushi KATOToshihiro MIURATomoji FUKUNAGA
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JOURNALS FREE ACCESS

1995 Volume 18 Issue 1 Pages 167-168

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Abstract

Two steroidal glycosides, PO-1 and PO-2, were tested as a new hypoglycemic drug. PO-2 showed remarkable hypoglycemic activity on i. p. injection into normal mice. PO-1 slightly lowered the blood glucose in normal mice. Furthermore, PO-1 and PO-2 exhibited significant hypoglycemic effects in streptozotocin-induced diabetic mice. However, a steroid, diosgenin, did not affect the blood glucose level in either normal or streptozocin-induced diabetic mice, indicating that the branching glucose units are essential for the biological activity.

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