3-Deoxyglucosone Reductase in Dog Adrenal Glands. Identification as Aldose Reductase

Kazuya MATSUURA; Kumiko SATO; Yoshihiro DEYASHIKI; Masayuki NAKANISHI; Akira HARA

doi:10.1248/bpb.18.1765

Kazuya MATSUURA, Kumiko SATO, Yoshihiro DEYASHIKI, Masayuki NAKANISHI, Akira HARA

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Keywords: adrenal gland, aldose reductase, 3-deoxyglucosone, glycation, β-keto acid ester

JOURNAL FREE ACCESS

1995 Volume 18 Issue 12 Pages 1765-1767

DOI https://doi.org/10.1248/bpb.18.1765

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Abstract

3-Deoxyglucosone is one of the major cytotoxic intermediates in the Maillard reaction. Adrenal glands showed the highest NADPH-linked 3-deoxyglucosone reductase activity of dog tissues. The enzyme was purified to homogeneity from the adrenal glands, and demonstrated to be structurally, functionally and immunologically identical with aldose reductase, which comprises about 6% of the soluble adrenal proteins.

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