Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Inhibitory Effect of Pyridobenzazoles on Virus Replication in Vitro
Takuo CHIBAShiro SHIGETAYoshio NUMAZAKI
Author information
JOURNALS FREE ACCESS

1995 Volume 18 Issue 8 Pages 1081-1083

Details
Abstract

Twelve species of pyridobenzazoles and pyrimidobenzimidazole were examined as inhibitors of the replication of respiratory syncytial virus (RSV) in HeLa cells. From the pyridobenzazoles studied, 2-benzamido-4-cyano-1-oxo-1H, 5H-pyrido [1, 2-α] benzimidazol emerged as a potent inhibitor of the RSV. Based on its inhibitory effect on the cytopathogenicity of the RSV in HeLa cells, the 50% effective dose was found to be 0.95μg/ml. The cytotoxicity of this compound for HeLa cells was examined by monitoring the incorporation of radiolabeled uridine into cellular RNA. The selectivity index was ca. 30, the same as Virazole.

Information related to the author
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top