Tuna Muscle Peptide, PTHIKWGD, Inhibits Leukocyte-Mediated Injury and Leukocyte Adhesion to Cultured Endothelial Cells

Yasuhiro KOHAMA; Takayuki KURODA; Susumu ITOH; Tsutomu MIMURA

doi:10.1248/bpb.19.139

Yasuhiro KOHAMA, Takayuki KURODA, Susumu ITOH, Tsutomu MIMURA

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Keywords: tuna peptide, endothelial cell, leukocyte, cell injury, cell adhesion

JOURNAL FREE ACCESS

1996 Volume 19 Issue 1 Pages 139-141

DOI https://doi.org/10.1248/bpb.19.139

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Abstract

Tuna muscle-derived angiotensin-converting enzyme inhibitory peptide, PTHIKWGD, inhibited the injury of bovine aorta endothelial cells (BAECs) induced by N-formyl-methionyl-leucyl-phenylalanine-activated polymorphonuclear leukocytes and the adhesion of a leukemia cell line, THP-1 cells, to BAECs stimulated by lipopolysaccharides. It is possible that this peptide directly affects BAECs, protecting them from activated leukocytes.

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