Stimulation of Sarcoplasmic Reticulum Ca²⁺-ATPase by Gingerol Analogues

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We have reported previously that [8]-gingerol increased Ca²⁺-ATPase activity. ^{1, 2)}Here we synthesized gingerol related compounds (AP-004, AP-005 and AP-015) and investigated the effects of gingerols ([6]-gingerol, [8]-gingerol and [10]-gingerol) and the synthesized compounds on the Ca²⁺-ATPase activity of sarcoplasmic reticulum (SR). The Ca²⁺-ATPase activity and the Ca²⁺-pumping activity increased by these compounds in a concentration-dependent manner. It is probable that both the o-methoxyphenol and hydrocarbon chain in the molecule of gingerol analogues are necessary for the activation of the Ca²⁺-pumping ATPase activity of SR.