Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Reduction of Oxazepam to Desmethyldiazepam by Human Intestinal Bacteria
Toshio OKAMURA, Wataru SUGIURA, Mitsuo MIYAZAWA
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Keywords: oxazepam, desmethyldiazepam, biotransformation intestinal bacteria, Bifidobacterium bifidum
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1996 Volume 19 Issue 4 Pages 647-648

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Abstract
The biotransformation of oxazepam by Bifidobacterium bifidum was studied. The major metabolite was purified by chromatographic methods and found to be desmethyldiazepam using NMR, IR and other physicochemical data.
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© The Pharmaceutical Society of Japan
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