POTENT ANTIHEPATOTOXIC ACTIVITY OF DICAFFEOYL QUINIC ACIDS FROM PROPOLIS

Purusotam BASNET; Katsumichi MATSUSHIGE; Koji HASE; Shigetoshi KADOTA; Tsuneo NAMBA

doi:10.1248/bpb.19.655

Purusotam BASNET, Katsumichi MATSUSHIGE, Koji HASE, Shigetoshi KADOTA, Tsuneo NAMBA

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Keywords: propolis, methyl 3, 4-di-O-caffeoyl quinate, 3, 4-di-O-caffeoyl quinic acid, hepatoprotective activity, liver

JOURNAL FREE ACCESS

1996 Volume 19 Issue 4 Pages 655-657

DOI https://doi.org/10.1248/bpb.19.655

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Abstract

Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3, 4-di-O-caffeoyl quinate (1) and 3, 4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepatotoxic agents than glucyrrhizin.

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