Absorption of Oligodeoxynucleotide by Suppository from Rat Rectal Route

Abstract

Rectal absorption of 32-mer phosphorothioate deoxynucleotides (S-Oligo) in the rat was attempted with the aid of a suppository containing oleic acid and a surfactant. Although, the suppository without adjuvant did not show detectable blood levels, that containing over 10% oleic acid enabled the absorption of S-Oligo with t_max at 2 h postdosing.