Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
mRNA Expression and cDNA Sequences of β- and γ-Sarcoglycans Are Normal in Cardiomyopathic Hamster Heart
Hironori HANADATomokazu YOSHIDAYan PANYuko IWATAMasahiko NISHIMURAMunekazu SHIGEKAWA
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1997 Volume 20 Issue 2 Pages 134-137

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Abstract

In BIO14.6 cardiomyopathic hamster heart, the dystrophin-glycoprotein complex is disrupted and sarcoglycans are greatly reduced in abundance. We examined whether the gene expression of β- and γ-sarcoglycans is indeed defective in this hamster. We found that mRNA expression for these proteins and the cDNA sequences of their coding regions are identical in both normal and myopathic hamster cardiomyocytes. The results strongly suggest that defect in a currently unknown sarcoglycan-associated protein(s) is responsible for the deficiency of the sarcoglycan complex that leads to muscle cell necrosis in the myopathic hamster.

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© The Pharmaceutical Society of Japan
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