CP2289, a New 5-HT3 Receptor Ligand : Agonistic Activities on Gastroenteric Motility

Yasuo SATO; Megumi IMAI; Kazuko AMANO; Katsuyoshi IWAMATSU; Fukio KONNO; Yasushi KURATA; Shiro SAKAKIBARA; Mitsugu HACHISU; Masaaki IZUMI; Norio MATSUKI; Hiroshi SAITO

doi:10.1248/bpb.20.752

CP2289, a New 5-HT₃ Receptor Ligand : Agonistic Activities on Gastroenteric Motility

Yasuo SATO, Megumi IMAI, Kazuko AMANO, Katsuyoshi IWAMATSU, Fukio KONNO, Yasushi KURATA, Shiro SAKAKIBARA, Mitsugu HACHISU, Masaaki IZUMI, Norio MATSUKI, Hiroshi SAITO

著者情報

キーワード: CP2289, 5-HT₃ receptor, agonist, antagonist

ジャーナルフリー

1997 年 20 巻 7 号 p. 752-755

DOI https://doi.org/10.1248/bpb.20.752

詳細

抄録

A new 5-HT₃ receptor ligand, CP2289, was synthesized and pharmacologically tested. Although CP2289 inhibited the Bezold-Jarisch reflex, it contracted the excised ileal muscle of mice, rats and guinea pigs. This response may reflect a partial agonist character of CP2289 in the gut. In vivo antiemetic and gastric emptying tests gave similar results.

責任著者(Corresponding author)

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