Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Anandamide, an Endogenous Cannabinoid Receptor Ligand, Also Interacts with 5-Hydroxytryptamine (5-HT) Receptor
Toshiyuki KIMURATomoko OHTAKazuhito WATANABEHidetoshi YOSHIMURAIkuo YAMAMOTO
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1998 Volume 21 Issue 3 Pages 224-226

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Abstract

Interactions of anandamide (N-arachidonylethanolamide), an endogenous compound for cannabinoid receptors, with the receptors for 5-hydroxytryptamine (5-HT), benzodiazepine, and γ-aminobutyric acidA (GABAA) receptors in bovine synaptic membrane were examined. Anandamide decreased the 5-HT receptor bindings at concentrations of 1-100 μM, although it did not cause any change in benzodiazepine or GABAA receptor bindings. A high concentration of anandamide, 100μM, significantly decrease both [3H]5-HT and [3H]ketanserin bindings. The present study revealed that the pharmacological activity of anandamide might be partially mediated through the 5-HT receptor.

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