Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Use of Hemoglobin as an Iron Source by Bacillus cereus
Noriyasu SATOHaruhiko KUROTAKIToshihiko WATANABETakeshi MIKAMITatsuji MATSUMOTO
Author information
JOURNALS FREE ACCESS

1998 Volume 21 Issue 4 Pages 311-314

Details
Abstract

The hemoglobin binding activity of Bacillus cereus cells was measured with fluoresceinisothiocyanate (FITC)-conjugated hemoglobin using flow cytometry. Growth of B. cereus was markedly inhibited by the addition of apo-transferrin. B. cereus could not use transferrin-bound iron as an iron source in serum. The growth inhibition was reversed by the addition of a FeCl3 solution, erythrocytes or hemoglobin. B. cereus released hemolysin; these findings suggested that the hemoglobin released from erythrocytes by B. cereus hemolysin binds to B. cereus and is thus used as an iron soruce.

Information related to the author
© The Pharmaceutical Society of Japan
Next article
feedback
Top