Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Inhibitory Effect of 2, 5-Dimethylpyrazine on Oxytocic Agent -induced Uterine Hypercontraction of Normal or Pregnant Female Rats
Kenji Yamada, Yoshiharu Kobayashi, Hisato Fujihara, Akihiro Ohta
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Keywords: 2, 5-Dimethylpyrazine, Rat uterus, Contraction, Oxytocin, Prostaglandin F2α
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1998 Volume 21 Issue 5 Pages 538-540

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Abstract
Intraperitoneal administration of 2, 5-dimethylpyrazine (2, 5-DMP) was found to inhibit oxytocin- and prostaglandin F2α -induced tetanic uterine contractions in normal or pregnant female rats. This suggests that 2, 5-DMP may be used as a countercontraction agent or relaxant for preventing oxytocic agent-induced medical accident including uterine rupture or pressure death of the fetus due to uterine contractions.
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© The Pharmaceutical Society of Japan
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