Inhibitory Effect of 2, 5-Dimethylpyrazine on Oxytocic Agent -induced Uterine Hypercontraction of Normal or Pregnant Female Rats

Kenji Yamada; Yoshiharu Kobayashi; Hisato Fujihara; Akihiro Ohta

doi:10.1248/bpb.21.538

Kenji Yamada, Yoshiharu Kobayashi, Hisato Fujihara, Akihiro Ohta

著者情報

キーワード: 2, 5-Dimethylpyrazine, Rat uterus, Contraction, Oxytocin, Prostaglandin F_2α

ジャーナルフリー

1998 年 21 巻 5 号 p. 538-540

DOI https://doi.org/10.1248/bpb.21.538

詳細

抄録

Intraperitoneal administration of 2, 5-dimethylpyrazine (2, 5-DMP) was found to inhibit oxytocin- and prostaglandin F_2α -induced tetanic uterine contractions in normal or pregnant female rats. This suggests that 2, 5-DMP may be used as a countercontraction agent or relaxant for preventing oxytocic agent-induced medical accident including uterine rupture or pressure death of the fetus due to uterine contractions.

責任著者(Corresponding author)

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