Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Metabolism of Puerarin and Daidzin by Human Intestinal Bacteria and Their Relation to in Vitro Cytotoxicity
Dong-Hyun KIMKi-Ung YUEun-Ah BAEMyung Joo HAN
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1998 Volume 21 Issue 6 Pages 628-630

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Abstract

When puerarin or daidzin were incubated for 24h with human intestinal bacteria, two metabolites, daidzein and calycosin, were produced from them, respectively. The metabolic time course of puerarin was as follows : at an early time, puerarin was converted to daidzin, and then calycosin. The metabolic time course of daidzin by human intestinal bacteria was also similar to that of puerarin. The in vitro cytotoxicities of these metabolites, calycosin and dadizein, were superior to those of puerarin and daidzein.

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© The Pharmaceutical Society of Japan
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