Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Trypanocidal Effects of Curcumin in Vitro
Mitsuhiko NOSETatsuo KOIDEYukio OGIHARAYoshisada YABUNobuo OHTA
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1998 Volume 21 Issue 6 Pages 643-645

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Abstract

During the course of study searching for the antiparasitic agents from natural compounds, we found that curcumin showed cytotoxicity against African trypanosomes in vitro. The LD50 values of curcumin were 4.77±0.91μM for bloodstream forms and 46.52±4.94μM for procyclic forms of Trypanosoma brucei brucei (GUTat 3.1 clone).

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