Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Anthraquinones from Neonauclea calycina and Their Inhibitory Activity against DNA Topoisomerase II
Hideki TOSAMunekazu IINUMAFujio ASAIToshiyuki TANAKAHiroshi NOZAKIShougo IKEDAKen TSUTSUIKimiko TSUTSUIMasashi YAMADAShiho FUJIMORI
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1998 Volume 21 Issue 6 Pages 641-642

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Abstract

In a series of searches fot DNA topoisomerase II inhibitors from naturally occurring compounds, a wood extract of Neonauclea calycina MERR. (Rubiaceae) showed a moderate effect in vitro. Purification of the extract resulted in the isolation of seven known anthraquinones. The structures were characterized as damnacanthal, rubiadin 1-methyl ether, nordamnacanthal, morindone, damnacanthol, lucidin 3-O-primeveroside and morindone 6-O-primeveroside by spectral analysis, respectively. Damnacanthal and morindone showed an intensive inhibitory effect against topoisomerase II (IC50 : 20μg/ml and 21μg/ml).

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© The Pharmaceutical Society of Japan
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