Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
An Antivirally Active Sulfated Polysaccharide from Sargassum horneri (TURNER) C.AGARDH
Tomomi HOSHINOToshimitsu HAYASHIKyoko HAYASHIJin HAMADAJung-Bum LEEUshio SANKAWA
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1998 Volume 21 Issue 7 Pages 730-734

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Abstract

A sulfated polysaccharide was isolated from the hot water extract of a brown alga, Sargassum horneri (TURNER) C.AGARDH. Fucose was detected as the main component sugar of this polysaccharide. This compound showed potent antiviral activity against herpes simplex virus type 1, human cytomegalovirus and human immunodeficiency virus type 1. Time-of-addition experiments suggested that it inhibited not only the initial stages of viral infection, such as attachment to and penetration into host cells, but also later replication stages after virus penetration.

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© The Pharmaceutical Society of Japan
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