Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Antimalarial Activity and Nucleoside Transport Inhibitory Activity of the Triterpenic Constituents of Cimicifuga spp.
Masayuki TAKAHARAAkiko KUSANOMakio SHIBANOGenjiro KUSANOKenzo KOIZUMIRyuji SUZUKIHye-Sook KIMYusuke WATAYA
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1998 年 21 巻 8 号 p. 823-828

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The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on teh triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 μM, and 19 of the compounds had a common 16, 23 : 23, 26 : 24, 25-triepoxy group in the side-chain moieties. Among the active triterpenoids. 9 also showed significant inhibition of nucleoside transport in mouse spleocytes A relationship between the antimalarial, activity and the inhibition of nucleoside transport involving these triterpenoids is discussed.

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© The Pharmaceutical Society of Japan
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