Studies of the Active Substances in Herbs Used for Hair Treatment. III. Isolation of Hair-Regrowth Substances from Polygara senega var. latifolia TORR. et GRAY

Hitoshi ISHIDA; Yasunori INAOKA; Masanori OKADA; Makoto FUKUSHIMA; Hirotatsu FUKAZAWA; Kuniro TSUJI

doi:10.1248/bpb.22.1249

Hitoshi ISHIDA, Yasunori INAOKA, Masanori OKADA, Makoto FUKUSHIMA, Hirotatsu FUKAZAWA, Kuniro TSUJI

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Keywords: Polygara senega var. latifolia, senegose A, senegin II, senegin III, C₃H/He mouse, hair regrowth

JOURNAL FREE ACCESS

1999 Volume 22 Issue 11 Pages 1249-1250

DOI https://doi.org/10.1248/bpb.22.1249

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Abstract

Four active principles, 1, 2, 3 and 4, were isolated from Polygara senega var. latifolia TORR. et GRAY by a combination of partition and column chromatography on silica gel and octadecyl silica gel (ODS), monitored by a hair-regrowth activity assay. Compounds 1, 2, 3 and 4 were identified as senegose A, senegin II, senegin III, and senegasaponin b by comparison of their spectral data with those of authentic samples.

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