Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide

Rumiko SHIMAZAWA; Hiroyuki MIYACHI; Hisae TAKAYAMA; Kensei KURODA; Fuminori KATO; Masanari KATO; Yuichi HASHIMOTO

doi:10.1248/bpb.22.224

Biological and Pharmaceutical Bulletin

Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158

Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide

Rumiko SHIMAZAWA, Hiroyuki MIYACHI, Hisae TAKAYAMA, Kensei KURODA, Fuminori KATO, Masanari KATO, Yuichi HASHIMOTO

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Keywords: thalidomide, antiangiogenesis, phthalimide, tumor necrosis factor-α

JOURNAL FREE ACCESS

1999 Volume 22 Issue 2 Pages 224-226

DOI https://doi.org/10.1248/bpb.22.224

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Abstract

Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived fromthalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.

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