Continuous Microinstillation of Phenol Red on Liver Surface for Liver Site-Selective Delivery

Junzo NAKAMURA; Yayoi YOSHIDA; Kunihiro MERA; Takahiro MUKAI; Koyo NISHIDA; Hitoshi SASAKI

doi:10.1248/bpb.22.713

Junzo NAKAMURA, Yayoi YOSHIDA, Kunihiro MERA, Takahiro MUKAI, Koyo NISHIDA, Hitoshi SASAKI

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Keywords: drug delivery system, liver, continuous microinstillation, liver surface, phenol red

JOURNAL FREE ACCESS

1999 Volume 22 Issue 7 Pages 713-715

DOI https://doi.org/10.1248/bpb.22.713

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Abstract

We report a very promising approach for liver site-selective drug delivery through drug instillation on liver surface. Phenol red, which was selected as a model drug, was accumulated in the instillation site after instillation on the rat liver surface. The site-selective localization was enhanced by gradually and continuously instilling a small amount of drug solution on the liver surface.

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