Abstract
Semi-synthetic tetrahydroisoquinoline derivatives prepared from natural alkaloids, possess Ca2+ antagonistic properties. These derivatives significantly blocked KCl-stimulated Ca2+ uptake (In chick and rat crude nerve ending) which can be partially inhibited by the selective N-type Ca2+ channel blocker ω-conotoxin GVIA or the selective P-type Ca2+ channel blocker ω-agatoxin IVA. Moreover, PX42 (10 μM; for the tetrahydroisoquinoline compounds in this study) could inhibit the activity of calmodulin-dependent phosphodiesterase and block veratridine-induced (or tetrodotoxin-sensitive) Na+ uptake. The possible mechanism(s) of non-selective inhibition of ion channels of PX42 is discussed.
