Biomedical Research on Trace Elements
Online ISSN : 1880-1404
Print ISSN : 0916-717X
ISSN-L : 0916-717X
原著
Plasma Zinc Disposition in Subjects with Low Zinc Levels Following Administration of Polaprezinc (Zinc L-Carnosine Complex)
Hiroyuki YanagisawaToru KawashimaSigeru FurutaYuji ShibasakiOsamu Yotsuya
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ジャーナル フリー

2013 年 24 巻 4 号 p. 185-189

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1.The plasma zinc disposition following administration of polaprezinc (Zinc L-Carnosine Complex) in six male subjects with an initial low serum zinc levels (<70 μg/dL) were compared to those in nineteen subjects with normal zinc levels.
2.The plasma zinc concentration reached a maximum plasma concentration (Cmax; 191 ± 30 μg/dL) at 1.83 h and returned to baseline level at 6 h after administration of 75 mg of polaprezinc (containing 17 mg of zinc). The plasma zinc concentration decreased at a half-life of 3.44 h. The area under the curve for plasma concentrations over time (0-12 h after administration; AUC0-12) was 1275 ± 138 μg•h-1•dL-1.
3.The plasma zinc level returned to the initial values at 6 h. It then decreased to values lower than those at baseline at 8 and 12 h following administration of polaprezinc.
4.In comparison with data from subjects with a normal zinc level, the absorption of zinc in subjects with low serum zinc following administration of polaprezinc was relatively low, and the deviation of AUC0-12 was minimal.

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© 2013 by Japan Society for Biomedical Research on Trace Elements
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