抄録
In rheumatoid arthritis and osteoarthritis it is observed that the streptokinase-added fibrinolytic activity of the synovial fluid is higher than the normal value and the inhibitor is increased. There is almost a parallel relationship between the amount of synovial fluid and the streptokinase-added fibrinolytic activity. In most cases the accumulation of the fluid in hydrarthrosis of rheumatoid arthritis and osteoarthritis can be prevented by an antiplasmin preparation. In hemarthrosis the plasminogen activator of the rabbit knee joint synovial membrane decreases somewhat temporarily and then increases. In experimental turpentine oil arthritis it increases temporarily from the beginning. By injecting plasmin into the rat intraperitoneally or intraarticularly the decrease of metachromasia of the epiphyseal cartilage and articular cartilage, disturbance of proliferation of the chondrocytes and fraying of the surface of the articular cartilage were observed.
