中和滴定法によるL-リシン塩酸塩の純度測定の高精度化と不確かさの評価

抄録

The quantitative analysis of amino acid is widely used in many analysis fields. Purity evaluations of amino acids are essential to prepare accurate calibration solutions for amino acid analysis. In this paper, the purity determination of L-lysine hydrochloride with using neutralization titration is discussed. Removing hydrogen chloride from a sample solution of L-lysine hydrochloride is important to determine the purity by neutralization titration. For an accurate purity determination of L-lysine hydrochloride, the condition in sample preparation was optimized. Under the optimized conditions, the purity of L-lysine hydrochloride could be determined with 0.03 % to 0.07 % of repeatability. The uncertainty of the measurement could be estimated at about 0.1 %. Moreover, the determined purity value was in good agreement with the purity value from nitrogen analysis. The optimized condition is valid for the purity analysis of lysine hydrochloride.