抄録
Authors have questioned for years why sulfonamides are ineffective in vitro despite their frequent clinical efficacy. The advent of sulfamethoxazole (SMX) -trimethoprim (TMP) combination product has provided an occasion to study this problem again. A significant number of isolated organisms were found to be sensitive to SMX alone whereas practically all strains were sensitive to the SMX-TMP combination in vitro. Untoward reactions, such as exanthem and photosensitivity, which are not infrequently encountered with sulfonamide drugs alone appeared to be as common with this new combination preparation.
