抄録
a. Antibacterial activities of sulfamethoxazole (SMX) and trimethoprim (TMP) alone and in 20 : 1 combination, have been studied against 14 strains of Staphylococcus epidermidis, 14 strains of Corynebacterium acnes and 28 strains of Staphylococcus aureus isolated from pyodermic lesions. In vitro antibacterial activities were assessed by the agar dilution method. Minimal inhibitory concentrations (MICs) for strains of Staphylococcus epidermidis and Staphylococcus aureus were found to be similarly distributed, i. e., SMX exhibiting low activity while TMP registering marked activities. The potentiation of antimicrobial activities by the combination of SMX and TMP was demonstrated in these strains. A similar tendency has also been found in the sensitivity pattern of Corynebacterium acnes against SMX and TMP alone and in combination.
b. A clinical trial in 4 cases of acne vulgaris and 8 cases of acne pustulosis revealed that SMX-TMP combination product was effective in 4 of the 10 evaluable cases. Two patients complained of subjective s.de effects, i. e., epigastric pain in 1 and epigastric discomfort associated with nausea in another.
