当科における1968年から1974年の間の分離菌種の年次的変動と化学療法剤感受性の変遷

抄録

The isolation frequencies and the resistance to antibiotics of various bacterial species from patients in the Department of Obstetrics and Gynecology of Tokyo Dental College, Ichikawa Hospital were studied in 1968, 1970, 1972 and 1974.
Antibiotics used for the sensitivity studies included ; ampicillin (ABPC), cephalexin (CEX), cephalo-ridine (CER), nalidixic acid (NA), streptomycin (SM) and kanamycin (KM).
The results obtained were as follows :
1. The isolation frequency of gram-negative bacilli had increased from 30. 96% in 1968 to 69. 49% in 1974. Among many of the gram-negative bacilli, E. coli showed the most remakable increase.
2. The isolation frequency of gram-positive cocci was 69. 49% in 1968 and decreased to 30. 50% in 1974.
3. Sensitive strains of gram-negative bacilli (E. coli, Klebsiella, and Proteus) to ABPC, CEX and CER have been decreasing yearly, but those to NA, SM and KM were almost unchanged.
4. The increased incidence of the resistance of Staphylococcus aureus to ABPC was noted, but incidence of the resistance of Staphylococcus aureus to CEX, SM and KM had not significantly increased.
5. Streptococcus faecalis has shown good sensitivity to ABPC, but the incidence of its resistance to CEX, CER, NA, SM and KM has rapidly increased.