Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Review Article
Dilated Cardiomyopathy
Concepts Derived From Gene Deficient and Transgenic Animal Models
John Ross Jr
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JOURNALS FREE ACCESS

2002 Volume 66 Issue 3 Pages 219-224

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Abstract

Genetic forms of human dilated cardiomyopathy (DCM) are briefly discussed, and a variety of animal models of genetic DCM are presented, some of which are caused by the gene mutations that also cause DCM in humans. The forms of DCM related to mutations or deletion of genes coding for extrasarcomeric or intrasarcomeric proteins, as well as to overexpression or knockout of genes in the β-adrenergic signaling pathway, are included. Finally, novel approaches to treatment in experimental animal models are discussed, including double transgenesis and newer recombination methods, as well as in vivo somatic gene transfer which, based on initial experiments in animals, seems likely to find eventual application in human cardiac failure. (Circ J 2002; 66: 219 -224)

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© 2002 THE JAPANESE CIRCULATION SOCIETY
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