Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Rapid Communication
TWEAK Can Induce Pro-Inflammatory Cytokines and Matrix Metalloproteinase-9 in Macrophages
Se-Hwa KimYoon-Joong KangWon-Jung KimDong-Kyun WooYoon LeeDong-Ik KimYong Bok ParkByoung S. KwonJeong-Euy ParkWon-Ha Lee
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2004 Volume 68 Issue 4 Pages 396-399

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Abstract

The expression of TWEAK (TNFSF12) and TweakR/Fn14 was detected in regions rich in macrophage/foam cells in atherosclerotic plaques. The role of TWEAK in monocytes in relation to atherogenesis was investigated by analyzing the cellular events induced by TWEAK in a human macrophage-like cell line, THP-1. TWEAK induced various molecular mediators of atherogenesis, such as IL-6, MCP-1, IL-8 and MMP-9, and the induction was augmented by interferon-γ. TWEAK-induced activation of MMP-9 was mediated by activation of NF-κB. These results suggest that TWEAK is involved in atherosclerosis by inducing pro-inflammatory cytokines and extracellular matrix degrading enzymes, which reduce plaque stability. (Circ J 2004; 68: 396 - 399)

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© 2004 THE JAPANESE CIRCULATION SOCIETY
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