Effects of Glucose Abnormalities on In-Hospital Outcome After Coronary Intervention for Acute Myocardial Infarction

Abstract

Background The effects of glucose abnormalities on outcomes after percutaneous coronary intervention (PCI) remain unclear. We examined the association between glucose abnormalities and in-hospital outcome in patients undergoing PCI for acute myocardial infarction (AMI). Methods and Results A total of 849 patients with AMI who were admitted within 12 h after symptom onset and underwent emergency PCI were classified according to the presence or absence of admission hyperglycemia, defined as a blood glucose level on admission of >11 mmol/L and whether they had a history of diabetes mellitus: group 1 (n=504), non-diabetic patients without admission hyperglycemia; group 2 (n=111), diabetic patients without admission hyperglycemia; group 3 (n=87), non-diabetic patients with admission hyperglycemia; and group 4 (n=147), diabetic patients with admission hyperglycemia. Among groups 1, 2, 3 and 4, in-hospital mortality was 2.6, 2.7, 11.5 and 8.8%, respectively (p<0.01). Multivariate analysis showed that compared with group 1 patients, the odds ratio (95%confidence interval) for in-hospital mortality among those in groups 2, 3, and 4 were 0.80 (0.24-2.60, p=0.708), 2.29 (1.10-5.49, p=0.039), and 2.14 (1.14-4.69, p=0.048), respectively. Conclusions In-patients undergoing PCI for AMI, admission hyperglycemia, irrespective of the presence or absence of diabetes, is associated with increased in-hospital mortality, whereas diabetes without admission hyperglycemia is not. (Circ J 2005; 69: 375 - 379)