Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Myocardial Creatine Concentration in Various Nonischemic Heart Diseases Assessed by 1H Magnetic Resonance Spectroscopy
Ichiro NakaeKenichi MitsunamiShinro MatsuoToshiro InubushiShigehiro MorikawaTakayoshi TsutamotoTerue KohMinoru Horie
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2005 Volume 69 Issue 6 Pages 711-716


Background Previous 31P magnetic resonance spectroscopy (MRS) studies demonstrated that the myocardial phosphocreatine-to-ATP ratio offered important information concerning the degree of dysfunction and prognosis in patients with cardiomyopathy. In the present study, we investigated total creatine (CR) levels in various diseased hearts using 1H MRS. Methods and Results Fourteeen patients with the following conditions were examined: cardiac amyloidosis (n=2); hypertensive heart disease (4); valvular disease (2); hypertrophic cardiomyopathy (2); dilated cardiomyopathy (2); restrictive cardiomyopathy (1); and post-operative atrial septal defect (1). Myocardial CR was measured using 1H MRS with point-resolved spectroscopy localization. Overall, myocardial CR levels in diseased hearts were significantly lower than those in the control group [16.5±6.0 (n=14) vs 27.1±3.2 μmol/g (n=10), p<0.001]. There was a positive correlation between myocardial CR and left ventricular ejection fraction (42.9±13.8%, range 19.5-69.1%) despite the different mechanisms of cardiac dysfunction (r=0.60, p<0.05). Myocardial CR levels in patients who were hospitalized due to heart failure within 1 year were significantly lower than those in other patients [11.3±1.0 (n=4) vs 18.6±5.9 μmol/g (n=10), p<0.05]. Conclusions Noninvasive measurement of myocardial CR using 1H MRS may be valuable in the assessment of disease severity and prediction of clinical course in various forms of heart disease. (Circ J 2005; 69: 711 - 716)

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