Positive Pressure Ventilation Treatment Reduces Plasma Levels of Amino Terminal-Pro Brain Natriuretic Peptide in Congestive Heart Failure Patients With Sleep Apnea

Zhi-Hui Zhao; Zhi-Hong Liu; Qin Luo; Chang-Ming Xiong; Xin-Hai Ni; Jian Zhang; Shu Zhang; Yue-Jin Yang

doi:10.1253/circj.70.572

Clinical Investigation

Positive Pressure Ventilation Treatment Reduces Plasma Levels of Amino Terminal-Pro Brain Natriuretic Peptide in Congestive Heart Failure Patients With Sleep Apnea

Zhi-Hui Zhao, Zhi-Hong Liu, Qin Luo, Chang-Ming Xiong, Xin-Hai Ni, Jian Zhang, Shu Zhang, Yue-Jin Yang

Author information

Zhi-Hui Zhao
Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Zhi-Hong Liu
Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Qin Luo
Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Chang-Ming Xiong
Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Xin-Hai Ni
Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Jian Zhang
Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Shu Zhang
Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Yue-Jin Yang
Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Keywords: Congestive heart failure, Positive pressure ventilation, Sleep apnea

JOURNAL FREE ACCESS

2006 Volume 70 Issue 5 Pages 572-574

DOI https://doi.org/10.1253/circj.70.572

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Abstract

Background The purpose of the present study was to assess the short-term effects of positive pressure ventilation (PPV) on plasma amino terminal-pro brain natriuretic peptide (NT-proBNP) levels in patients with congestive heart failure (CHF) and sleep apnea (SA). Methods and Results Polysomnography was performed in 105 CHF patients. Twenty-six patients with CHF and SA were randomly assigned to a control group or a PPV group. Patients in the higher New York Heart Association classes had higher plasma levels of NT-proBNP. The plasma NT-proBNP concentration in the PPV group decreased. Conclusion Plasma NT-proBNP levels reflect the severity of CHF, and PPV can decrease plasma NT-proBNP levels in patients with CHF and SA. (Circ J 2006; 70: 572 - 574)

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