Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Chronic Kidney Disease is a Risk Factor for Cardiovascular Death in a Community-Based Population in Japan
NIPPON DATA90
Koshi NakamuraTomonori OkamuraTakehito HayakawaTakashi KadowakiYoshikuni KitaHirofumi OhnishiShigeyuki SaitohKiyomi SakataAkira OkayamaHirotsugu UeshimaThe NIPPON DATA90 Research Group
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2006 Volume 70 Issue 8 Pages 954-959

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Abstract

Background Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD). Methods and Results The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7% had CKD with a GFR <60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95% confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60≤ GFR <90, 1.15 (0.67-1.99) for a 45≤ GFR <60, 1.23 (0.49-3.09) for a 30 ≤ GFR <45, 5.52 (1.62-18.75) for a 15≤ GFR <30, 9.12 (2.12-39.29) for a GFR <15, as compared with normal kidney function (GFR ≥90). The proportion of excess cardiovascular death due to CKD was 1.3%. Conclusion CKD was an independent risk factor for cardiovascular death in a community-dwelling Japanese population. (Circ J 2006; 70: 954 - 959)

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© 2006 THE JAPANESE CIRCULATION SOCIETY
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