Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Clinical Protocol for Angiogenesis by Intramyocardial Injection of Autologous Bone Marrow Mononuclear Cells in Patients With Severe Coronary Artery Disease
Hideo IzawaTakahisa KondoAkihiko UsuiKoji YamamotoSatoshi ShintaniYasuya IndenSatoshi IsobeKazumasa UnnoMasahiro KajiguchiTomoko KatoAkiko NodaKenji OkumuraTomoki NaoeJunki TakamatsuKimihiro KomoriYuichi UedaToyoaki Murohara
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2006 Volume 70 Issue 9 Pages 1180-1183


Background Despite recent improvements in the treatments of coronary artery disease (CAD), there are a considerable number of patients who can not receive complete revascularization because of severe or total arterial occlusion. Intramyocardial injection of autologous bone marrow mononuclear cells (ABMMCs) has been shown to induce neovascularization of ischemic myocardium. Methods and Results The study will investigate the safety and feasibility of intramyocardial injections of ABMMCs and test the hypothesis that this treatment would promote neovascularization and improve left ventricular (LV) global and/or regional function in patients with severe CAD who have no other option. ABMMCs (~106 cells) will be injected into the area of ischemic myocardium where the coronary artery is not graftable, in combination with bypass surgery to the other coronary branches. Myocardial perfusion and LV global and regional function will be evaluated, based on the micromanometer-tipped catheter method, single-photon emission tomography, and myocardial enhanced and color tissue Doppler echocardiography at baseline and during 12 month follow-up. Conclusions This project will demonstrate that intramyocardial injection of ABMMCs with or without coronary artery bypass surgery could be a safe and effective method for therapeutic neovascularization, resulting in an improvement of cardiac function in patients with severe CAD. (Circ J 2006; 70: 1180 - 1183)

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