Circulation Journal
Clinical Investigation
Association of Atrial Arrhythmia and Sinus Node Dysfunction in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Naokata SumitomoHarumizu SakuradaKazuo TaniguchiMasaharu MatsumuraOsamu AbeMichio MiyashitaHiroshi KanamaruKensuke KarasawaMamoru AyusawaSeiji FukamizuIori NagaokaMinoru HorieKensuke HaradaMasayasu Hiraoka
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Volume 71 (2007) Issue 10 Pages 1606-1609

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Abstract

Background This study was performed to investigate the frequency and importance of supraventricular arrhythmia and sinus node (SN) dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT). Methods and Results Eight patients with CPVT (mean age: 16.8±8.1 years) underwent an electrophysiological study. SN recovery time (1,389±394 ms) was slightly prolonged, and 4 of 8 patients had abnormal values. Atrial flutter (AF) was induced by low-rate atrial pacing in 2 patients and by isoproterenol infusion in 1 patient. Atrial fibrillation (Af) was induced by isoproterenol infusion in 2 patients. One patient presented with Af during the follow-up period, and 2 of 4 patients with AF/Af presented with increased SN recovery time. Conclusions Patients with CPVT frequently have associated with SN dysfunction, and inducible atrial tachyarrhythmias, which indicate that the pathogenesis of CPVT is limited not only to the ventricular myocardium, but also to broad regions of the heart, including the SN and atrial muscle. (Circ J 2007; 71: 1606 - 1609)

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© 2007 THE JAPANESE CIRCULATION SOCIETY
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