Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Parathyroid Hormone and Vitamin D Levels are Independently Associated With Calcific Aortic Stenosis
Katerina LinhartováJosef VeselkaGabriela SterbákováJaroslav RacekOndrej TopolcanRoman Cerbák
Author information

2008 Volume 72 Issue 2 Pages 245-250


Background In calcific aortic valve disease, the early lesion is similar to atherosclerotic plaque, but later calcification prevails. Parathyroid hormone (PTH) and vitamin D are the principal calcium pool regulators, so the present study was designed to assess their association with aortic stenosis (AS) in patients with significant coronary artery disease (CAD), and preserved renal function. Methods and Results The 122 consecutive patients with AS (mean gradient ≥30 mmHg) plus CAD, and 101 patients with nonobstructive aortic sclerosis (mean gradient ≤10 mmHg) plus CAD, as controls, were prospectively enrolled. The AS patients were older (71±7 vs 66±7 years; p<0.001), had higher serum intact (i)PTH (51.4 [39-70] vs 37.4 [27-50] pg/ml; p<0.001), and lower plasma vitamin D (32.0 [25-40] vs 35.8 [27-55] nmol/L; p=0.003) levels than those with aortic sclerosis. The groups did not differ significantly in creatinine level (93 [82-105] vs 96 [85-107] μmol/L, p=0.19), calcium - phosphate product, occurrence of hypertension, smoking, diabetes, dyslipidemia, or body mass index. The iPTH (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.02-1.05; p<0.001) and vitamin D levels (OR 0.97, 95% CI 0.95-0.99; p=0.003) were independently associated with AS. Conclusion Higher serum iPTH with lower vitamin D levels were independently associated with calcific AS in CAD patients. (Circ J 2008; 72: 245 - 250)

Information related to the author
Previous article Next article